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Mean Corpuscular Hemoglobin concentration (MCHC)

Mean Corpuscular Hemoglobin concentration (MCHC)
September 22, 2020HematologyLab Tests

Sample

  1. It is done on blood in EDTA (anticoagulant).
  2. Whole blood stable 6 hours at 25 °C and 24 hours at 4 °C.
  3. Fetal blood collected by percutaneous umbilical blood.

Indication

  1. This is part of CBC (Complete blood count).
  2. This helps to diagnose the type of anemia.
  3. Mostly advised to diagnose macrocytic anemia.

Pathophysiology

  1. Definition: This is the measure of the average hemoglobin concentration or percentage of hemoglobin within a single RBCs.
    MCHC calculation formula

    MCHC calculation formula

  1. On the basis of MCHC RBCs may be classified into:
    1. Normochromic.
    2. Hypochromic.
  2. Both MCH and MCHC values are used to determine the content of Hemoglobin in the RBCs.
    1. If MCHC is normal then RBCs are referred to as normochromic.
    2. If MCHC is less than normal then RBCs are referred to as hypochromic.
  3. Hypochromic RBC when Decreased MCHC indicates low hemoglobin.
  4. The above normal level may be seen in alteration of RBC shape like spherocytosis, Transfusion reaction, and erythroblastosis fetalis.

Interfering factors are:

  1. The abnormal size of the RBCs may affect the MCHC.
  2. Increased level of lipids in the blood gives a high result because of high hemoglobin.

Normal

Source 1

Age g Hb/dL
Fetal blood
18 to 20 weeks 32.0 ± 2.3
21 to 22 weeks 31.7 ± 2.78
23 to 25 weeks 32.1 ± 3.20
26 to 30 weeks 32.1 ± 3.60
Cord blood 30 to 36
0.5 month 28 to 35
0ne month 28 to 36
2 month 28 to 35
4 month 29 to 37
6 to 12 month 32 to 37
1 to 2 year 32 to 38
3 to 11 year 32 to 37
Male Female
12 to 14 year 32 to 37 32 to 37
15 to 17 year 32 to 36 32 to 36
18 to 44 year 32 to 37 32 to 36
45 to 64 year 32 to 36 31 to  36
65 to 74 year 31 to 36 32 to 36
  • To convert into SI unit x 10 = g Hb/L

Source 2

  • Adult = 32 to 36 g/dL or 32 to 36%
  • Newborn = 32 to 33 g/dL or 32 to 33%.

Normal MCHC values seen in:

  • Normochromic anemia (hemolytic anemias).

Decreased values of MCHC seen in:

  1. When MCHC is < 30 g/dL.
    1. Hypochromic anemias :
      1. Iron deficiency anemia.
      2. Microcytic anemia.
      3. Chronic blood loss.
      4. Thalassemia.
Iron deficiency anemia blood picture

Iron deficiency anemia blood picture

Increased values of MCHC is seen in:

  1. Spherocytosis.
  2. Newborn and infants.
  3. Erythroblastosis fetalis.
  4. Intravascular hemolysis gives free hemoglobin which is calculated by the autoanalyzer.

Possible References Used
Go Back to Hematology

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