Carbon monoxide (CO) Poisoning
- Carbon monoxide has high affinity to bind with hemoglobin.
- This binding affinity as compared to oxygen is 200 times more.
- When it combines with Hemoglobin then give rise to Carboxyhemoglobin (Hb-CO.)
- Because of carbon monoxide (CO) binding then the sites for oxygen are not available.
- This has even more affinity for fetal hemoglobin.
- Carbon monoxide is directly toxic to intracellular oxidative process.
Clinical effects of Carbon monoxide poisoning
|Level of Carbon monoxide||Clinical effect on patient|
|0.4 to 2%||This level is seen in normal nonsmoker|
|2 to 6%||This level is seen in normal smoker|
|10 to 20%||Patient will have mild symptoms like dyspnea on exertion|
|20 to 50%||Symptoms are severe. There is intoxication with headache, lethargy and loss of consciousness|
|>50%||Patient will go into coma and ultimately death|