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Sample

Purpose of test

Pathophysiology

  1. The HBDH is alternate to determine the  LDH isoenzymes.
    1. Roasalki and Wilkinson advocated the ratio of LDH/HBDH.
    2. In healthy individual serum, the ration of LDH/HBDH varies from1.2 to 1.6.
      1. in liver parenchymal diseases is 1.6 to 2.5.
      2. While in heart disease (Myocardial infarction)  when LDH-1 and LDH-2 activity are increased and at the same time HBDH is also increased, then LDH/HBDH ratio is decreased to 0.8 to 1.2.
      3. LDH/HBDH ratio is more popular in the UK than the USA.
  2. The level of HBDH is usually detected within 12 hours of the infarction.
  3. Peak level is seen during 48 to 72 hours.

Normal

The increased level is seen in:

  1. Myocardial infarction.
  2. Muscular dystrophy.
  3. Megaloblastic anemia.
  4. Disseminated metastasis.

Possible References Used

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