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Posted Sept. 5, 2016. Pathology Pathology - Lymph node

REAL classification is Revised European – American classification of lymphoid neoplasm.

It includes :

  1. Lymphocytic leukemia
  2. Non – Hodgkin’s lymphoma
  3. Plasma cell tumors.

REAL classification is into 4 broad categories based on the immunophenotype.

  1. Precursor B – cell neoplasm (Neoplasm of mature B – lymphocytes).
  2. Peripheral B – lymphocyte neoplasm (Neoplasm of mature B – lymphocytes).
  3. Precursor T – lymphocyte neoplasm (Neoplasm of immature T – lymphocyte).
  4. Peripheral T – lymphocyte neoplasm (Neoplasm of mature T – lymphocyte)

Precursor B – lymphocyte = Precursor B – cell lymphoblastic leukemia/lymphoma.

Precursor T – lymphocyte = Precursor T – cell lymphoblastic leukemia/lymphoma.

Peripheral B – lymphocyte gives rise to:

  1. Chronic lymphocytic leukemia / small lymphocytic lymphoma.
  2. Lymphoplasmacytic lymphoma.
  3. Mantle cell lymphoma.
  4. Follicular lymphoma.
  5. Marginal zone lymphoma.
  6. Hairy cell leukemia.
  7. Plasmacytoma/plasma cell myeloma.
  8. Diffuse large cell (B) lymphoma.
  9. Burkitt’s lymphoma.

Peripheral T – cell and NK –  neoplasm give rise to:

  1. T cell chronic lymphocytic leukemia.
  2. Large granular lymphocytic leukemia.
  3. Angioimmunoblastic T – Cell lymphoma.
  4. Angiocentric lymphoma (NK – T – cell lymphoma).
  5. Intestinal T – cell lymphoma.
  6. Adult T – cell leukemia/lymphoma.
  7. Anaplastic large cell lymphoma.

 


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